The high frame rate scene simulation system based on DMD can realize the function and performance testing of high frame rate detection system in visible and infrared band, while the driving technique is the core of the whole simulation system. According to the hardware characteristics of DMD and the improved PWM method, the driver of the DMD control system is designed based on FPGA and can realize the PCIe high speed data transmission, DDR3 data access and high frame rate displaying of grayscale images based on DMD. At the same time, the PCIe driver of PC is designed by using WinDriver. The experimental results show that this driving technique can drive the simulation system to display 8bit grayscale images in 1000Hz, which can meet the test requirement of high frame rate detection system, and can be applied to construct high frame rate scene simulation systems in visible and infrared band.