For physiological characteristics of the mesoptic vision of human eyes, the evaluation method of the color rendering of LED road lighting power was studied. By constructing the luminous efficiency model in mesoptic vision of human eyes, corresponding spectral luminous efficiency curve and sensitive wavelength range of human eyes were obtained, the evaluation and calculation methods of color rendering of LED road lighting power based on mesoptic vision were given, the functional relationship between the intergrated color rendering index and the dominant wavelength of the light power was established and verified by the subjective experiment and objective definition calculation. Calculation and experimental results indicate that under the condition of meeting the road illumination brightness, the intergrated color rendering index of the light power reaches the largest when the main wavelength of the road lighting power is 548.5nm, and the intergrated color rendering performance is the best.